Aloe vera reduced the inflammation through microbial infection, lowering TNF-α level (Yun et al., 2009 ▶), decreasing leukocyte adhesion and TNF-α levels in rats infected with Helicobacter pylori (Prabjone et al., 2006 ▶), and improving the healing of the peptic ulcer by reducing the TNF-α level (Eamlamnam et al., 2006 ▶) in non-TBI cases. This evidence concerns the gene TNF and peptic ulcer disease.