HAVCR2 and neoplasm: Activation in the presence of CAFs induced phenotypic changes in both CD8+ (Figure 3a,b) and CD4+ (Figure 3c, d) T cells with upregulation of co-inhibitory receptors PD-1, Tim3 and LAG-3 as well as CD39 (Figure 3a,b) resulting in a phenotype resembling that of tumor infiltrating T cells (Figure 1a).