Overall, Fetuin-A level of autistic children (n = 46 and CARS score >30) exhibited significantly lower (p= 0.02) plasma level [50.76 (22.2-68.5)] ng/ml [median (interquartile range)] than those of healthy controls [53.7(35.6-99.7)] ng/ml [median (IQR)].There was also a significant (p=0.02) difference observed between the Fetuin-A level [50 (30-68.2)] ng/ml [median (IQR)] of mild to moderate autism (n = 24 and CARS score <36.5) and healthy controls [53.7(35.6-99.7)] ng/ml. The gene discussed is AHSG; the disease is autism.