Fetuin-A has been recognized as a biomarker for neurodegenerative disease10 and shows protective outcomes in inflammation.11 Recently Fetuin-A was also recognized as a possible biomarker in multiple sclerosis (MS) cerebrospinal fluid (CSF) of mice.12 Puchades et al13 compared the CSF proteome between controls and AD patients and identified that Fetuin-A is altered and contributed in the disease process and pathogenesis of AD. This evidence concerns the gene AHSG and myeloid sarcoma.