DBI and major depressive disorder: However, one study using multi-omics analyses revealed that reduced levels of diazepam-binding inhibitor (DBI) proteins including Fetuin-A were associated with severe language impairment in ASD.2 Furthermore, our findings were also consistent with earlier studies showed decreased levels of Fetuin-A in Alzheimer’s disease (ALD), major depressive disorder (MDD).8, 16 Though caution should be applied in the interpretation of our rdata, suggesting a possible role for Fetuin-A in ASD.