AHSG and early-onset autosomal dominant Alzheimer disease: The Fetuin-A protein is necessary for mineral homeostasis and demonstrates immunomodulatory roles, for instance to bind with TGF super family proteins.3 Fetuin-A has been revealed to have anti-inflammatory functions and it has neuroprotective effect in Alzheimer’s disease (AD).4 Reduced Fetuin-A Protein is an indicator of amplified disease action in ulcerative colitis, Crohn’s disease and obstructive lung disease.4 However, the pathophysiological role of Fetuin A in ASD is uncertain.