Inflammatory cytokine release from these cells induce adhesion molecule-mediated VCAM, ICAM monocyte activation and inflammatory cytokines (IL-1, IL-6, IL-18, CRP, TNF alpha etc.)are released Monocyte activation leads to chronic inflammation and atherosclerosis.10 These alterations cause changes in renal hemodynamics, GFR and blood pressure.11 The gene discussed is TNF; the disease is atherosclerosis.