Large, unbiased genome wide association studies (GWAS) later found TYK2 to be associated to a range of autoimmune diseases, including rs12720356 (I684S) with Crohn’s disease [odds ratio (OR) 1.12] (Franke et al., 2010) and psoriasis (OR 1.4) (Bowes et al., 2015), while AS was associated with an intergenic SNP near TYK2 (rs35164067, OR 1.16) (Cortes et al., 2013). This evidence concerns the gene TYK2 and autoimmune disease.