TYK2 and dermatitis: In addition, there have been publications involving dual TYK2 and JAK1 catalytic inhibitors; SAR-20347, blocked psoriasis-like skin inflammation in mice (Works et al., 2014) and PF-06700841 (brepocitinib), was found to be protective against adjuvant-induced arthritis in rats (Fensome et al., 2018).