Brepocitinib has since done well in both phase I and phase II trials, whereby it reduced C-reactive protein (CRP) by almost 50% and almost completely resolved skin inflammation in psoriasis patients (75% reduction in their psoriasis symptoms [PASI75] in ∼80% of subjects) (Banfield et al., 2018; Forman et al., 2020). The gene discussed is CRP; the disease is psoriasis.