TYK2 and Crohn disease: Large, unbiased genome wide association studies (GWAS) later found TYK2 to be associated to a range of autoimmune diseases, including rs12720356 (I684S) with Crohn’s disease [odds ratio (OR) 1.12] (Franke et al., 2010) and psoriasis (OR 1.4) (Bowes et al., 2015), while AS was associated with an intergenic SNP near TYK2 (rs35164067, OR 1.16) (Cortes et al., 2013).