AOX1 mRNA expression is significantly dysregulated in 23 out of 31 types of tumors, and one of the 23 types of tumors has upregulated AOX1 level, while 22 of the 23 types of tumors have downregulated AOX1 levels, including ccRCC (Figure 7B). This evidence concerns the gene AOX1 and nonpapillary renal cell carcinoma.