NCK2 can modulate cell motility by interacting with focal adhesion through its SH3/SH2 domain (Goicoechea et al., 2002) and may influence tumor aggressiveness by mediating cell–extracellular matrix interactions in ovarian cancer (Fanelli et al., 2018) and promote melanoma progression in vitro and in vivo (Labelle-Cote et al., 2011). The gene discussed is NCK2; the disease is melanoma.