Enriched KEGG pathways included those involved in ubiquitin-mediated proteolysis, erbB signaling pathway, cell cycle, neurotrophin signaling pathway, RIG-I–like receptor signaling pathway, colorectal cancer, endometrial cancer, influenza A, and insulin signaling pathway (Figure 2E; details can be found in Supplementary Table 5). The gene discussed is BDNF; the disease is endometrial cancer.