Among them, three core sub-networks, SNHG16, LIN01128, RP11-834C11.4(LINC02381)/hsa-let-7f-5p/IL6, LINC01128/has-miR-21-5p/PTX3, and LINC00665/hsa-miR-155-5p/PLS1 may serve as promising prognostic predictor sand therapeutic targets for SSc-ILD. This evidence concerns the gene PTX3 and interstitial lung disease.