Among the network, three core sub-networks, SNHG16, LIN01128, RP11-834C11.4(LINC02381)/hsa-let-7f-5p/IL6, LINC01128/has-miR-21-5p/PTX3, and LINC00665/hsa-miR-155-5p/PLS1, were considered to be of huge significance for the pathological development in SSc, by influencing LPS-induced inflammatory and immune processes, fibrosis development, and tumor microenvironment variations (Shah and Rosen, 2011; De Luca et al., 2015; Sambataro et al., 2015; Maria et al., 2018). This evidence concerns the gene PLS1 and systemic sclerosis.