HER2Bi or EGFRBi armed hCART41BBζ, hCARTICOS-27ζ and BATs induced robust levels of Th1 cytokines-IFN-γ and TNF-α upon tumor engagement at 1:1 E:T ratio compared to unarmed counterparts except for IL-2 that did not show any change in levels between armed hCART41BBζ and BATs compared to unarmed hCART41BBζ and BATs. This evidence concerns the gene TNF and neoplasm.