Taken together, these studies imply that using IgM could be problematic in providing a differential and accurate diagnosis because it could render: (i) a false-positive result due to the reaction to related viruses by CR-Abs (47–49), (ii) a false positive result of a current infection as a consequence of TS- or CR- long-lived IgM Abs (50), or (iii) a false negative result due to the absence of IgM in secondary flavivirus infections (46). The gene discussed is CD40LG; the disease is Flavivirus Infections.