We observed several immune modulating molecules such as Cd274, Ctla4 and Irf7 to be expressed by the cultured OSCC13 cells, mimicking HNSCC, 4NQO-induced tumors and the 4MOSC1-4 cells [Supplementary Table S3 (18, 24, 33)]. Here, CTLA4 is linked to head and neck squamous cell carcinoma.