We noticed effects on tumor immunity that can be considered to be anti-tumorigenic (e.g. abundant infiltration of macrophages, CD11c+ myeloid/dendritic cells, CD4+ and CD8+ TIL cells) but also pro-tumorigenic (e.g. high abundance of FRC as potential source for deposited matrix, co-localization of immune subtypes with matrix (reminiscent of retention by the matrix), numerous immune suppressive CD206+ M2 macrophages and Foxp3+ T reg cells and high PDL-1). The gene discussed is CD4; the disease is neoplasm.