Matias et al. (2006) had also reported enhanced insulin release due to incubation of rat insulinoma cells with HU-210, a CB1R agonist, when maintained on high glucose, and this effect was reversed by treatment with CB1R antagonist rimonabant, supporting the idea of a stimulatory role for ECs on insulin secretion (32). This evidence concerns the gene CNR1 and pancreatic insulinoma.