In the year 2021, when we celebrate the 100s anniversary of the discovery of insulin, it is just natural that the breakthrough of another family of secreted peptides of common origin from the proglucagon gene: GLP-1, GLP-2 and glucose-dependent insulinotropic polypeptide (GIP) with major implications on the therapy of diabetes was recognized and awarded (44). Here, GLP1R is linked to diabetes mellitus.