Dermatomyositis (DM)-associated antibodies routinely include anti-mitochondrial (Mi) 2α and β, anti-transcriptional intermediary factor 1γ (TIF1γ), anti-melanoma differentiation-associated protein 5 (MDA5), anti-nuclear matrix protein 2 (NXP2), and anti-small ubiquitin-like modifier activating enzyme 1 (SAE1) antibodies. The gene discussed is TRIM33; the disease is dermatomyositis.