The atrophy patterns associated with frontotemporal lobar degeneration (FTLD) have been found associated with family mutations in three genes, namely, chromosome 9 open-reading-frame 72 (C9ORF72), microtubule-associated protein tau (MAPT), and progranulin (GRN), and their clinical profiles are highly variable (7). The gene discussed is GRN; the disease is frontotemporal dementia.