Similarly, in a mouse model of cerebral ischemia, the blockade of irisin/FNDC5 can also weaken the protective effect of exercise on neurological deficits caused by cerebral ischemia; compared with the control group, the blocking of irisin/FNDC5 performed more serious neuronal damage (Li et al., 2017). Here, FNDC5 is linked to Cerebral ischemia.