MSCs-HGF reduced secretion and expression of proinflammatory cytokines, such as TNF-α, interferon-γ, interleukin (IL)-6, and intercellular adhesion molecule-1, increasing the expression level of anti-inflammatory cytokine IL-10 and decreasing the expression levels of profibrotic factors TGF-β, Col1a1 and Col3a1 culminating in the reduction of lung fibrosis progression (Wang et al., 2013) In another study from Chen and collaborators, rat bone marrow-derived MSCs transfected to express HGF increased MSCs viability, and inhibit the proinflammatory phenotype of MSCs in the inflammatory condition. Here, TGFB1 is linked to pulmonary fibrosis.