To this purpose, the common genetic variants associated with IPF are represented by gene involved in the airway mucin production (MUC5B, MUC2), cell-cell adhesion (DSP, DPP9) playing a critical role in the maintenance of epithelial integrity, innate and adaptive immune response (Toll-Like receptor signaling, TOLLIP, TLR3), cytokine and growth factor signaling (IL1RN, IL8, IL4, TGFβ1), telomere maintenance (TERT, OBFC1) and cell cycle regulation (KIF15, MAD1L1, CDKN1A, TP53) (Michalski and Schwartz, 2020). This evidence concerns the gene TGFB1 and idiopathic pulmonary fibrosis.