NOS3 and cardiovascular disorder: Regarding the NOS3 gene, the SNPs rs2070744 and rs1799983 have been widely studied as possible risk factors for cardiovascular diseases (Zhang et al., 2012; Nawaz et al., 2015), and rs1799983 was identified as a genetic biomarker of coronary artery disease in a meta-analysis of 132 case–control studies (Li et al., 2019).