HSP90 plays a key role in regulating the stability, maturation, and activation of a wide range of client substrates, including HER family members, STAT family members, Akt, cyclins and CDKs, that are essential for cancer cell survival and proliferation (Kamal et al., 2003; Kamal et al., 2004; Falsone et al., 2005; Zhao et al., 2005). This evidence concerns the gene AKT1 and cancer.