FOXO3 and Sepsis: In a study of sepsis-induced intestinal injury, Cx43 channels regulate ROS generation and distribution between intestinal epithelial cells, thus regulating the activity of the JNK1/Sirt1/FoxO3a signaling pathway, resulting in the expression of pro-apoptotic Bim and Puma and sepsis-induced intestinal injury aggravation (Zou et al., 2019).