While some synaptic mechanisms appear to utilize CP-AMPARs, aberrant expression of CP-AMPARs has been implicated in many neurological disorders where excessive activity leads to neurodegeneration (Weiss, 2011), including but not limited to epilepsy (Grooms et al., 2000; Rajasekaran et al., 2012; Malkin et al., 2016), ischemia (Kwak and Weiss, 2006), traumatic brain injury (Spaethling et al., 2008), and illicit substance addiction and withdrawal (Pistillo et al., 2016; Wolf, 2016). Here, CP is linked to ischemia.