In particular the corpus callosum was implicated by our analyses, in line with previous neuroimaging findings on TMEM106B (Adams et al., 2014), with higher volume of several callosal subregions for carriers of the rs5011436 c-allele, the allele that we found to convey risk for depression and to be protective for AD. The gene discussed is TMEM106B; the disease is depressive symptom measurement.