Thirty-three out of the forty-five DEGs were identified to be significantly associated with the OS of PAAD patients, and seven of them (ANO1, FAM83A, GPR87, ITGB6, KLK10, SERPINE1, and SMIM32) were identified by the LASSO model to construct an LM-PS for predicting the OS of PAAD patients post R0 resection. This evidence concerns the gene KLK10 and pancreatic adenocarcinoma.