CD8A and neoplasm: TOX, which encodes a chromatin modifier important for exhaustion programs of chronic virus-specific and tumour-specific T cells in mouse models21,22, was only marginally increased in MANA-specific cells, whereas its homologue, TOX2, which has also been reported to drive T cell exhaustion23, showed much higher upregulation in MANA-specific versus EBV-specific CD8 TIL.