Notably, 4 of the 41 MANA-specific TCRVβ complementarity-determining region 3 (CDR3) clonotypes identified in a patient without MPR (patient ID MD01-004) (Extended Data Fig. 2) were specific for a MANA (MD01-004-MANA12) derived from a p53 R248L hotspot mutation, and were found at appreciable frequency in the pre- and post-treatment tumour (Extended Data Fig. 3), despite the tumour not attaining MPR. The gene discussed is TP53; the disease is neoplasm.