Thus, in addition to impairing DC recruitment, suppressing DC maturation, and inhibiting the production of TNF-α, IL-12, and IFN in DCs, TGF-β also promotes the development of immature and tolerogenic DCs, contributing to impaired T cell anti-tumor responses by inducing IL-10 and further TGF-β production [103, 104]. The gene discussed is IL10; the disease is neoplasm.