Furthermore, by characterising the genome-wide expression signature associated with the 3-genes-positive aggressive tumours and comparing it with that of a cell line where CCNA1, one of the three genes, had been down-regulated, we observed a shift of this transcriptomic signature towards that of the less aggressive form of OSCC, suggesting that CCNA1 could be a good target for therapeutic approaches. Here, CCNA1 is linked to neoplasm.