Conditional knockout of CISH led to increased interferon-γ production and augmented anti-tumor responses in CD8+ T cells14 or NK cells.15 In the case of NK cells, this related to enhanced metabolic fitness that favored survival and proliferation under conditions of limiting cytokines like IL-2 and IL-15.16 In addition to generalized inhibition, some reports suggest that CISH imparts differential control across activation programs in the same cells. The gene discussed is CISH; the disease is neoplasm.