SDC1 and Miyoshi myopathy: Thus, these studies reveal heterogeneity in the proportion of immune cell subsets among patients with MGUS, SMM, or MM, and healthy individuals; decreased effector cells, increased Treg, and G-type MDSC, as well as upregulation of immune checkpoints on effector, regulatory, and CD138+ MM cells are observed in MM patients compared to patients with MGUS or SMM or healthy individuals.