In it, Bagnato et al.9 reported that in an age- and sex-matched control autopsy series, 56 of the fatal SSc patients had histologic evidence of severe fibrosis of the thyroid glands (i.e., 14% vs. 2% of pathologic vs. serologic cases).All of thyroid tissue of SSc patients with hypothyroidism had fibrosis with some lymphocytic infiltration, and in 6 of 7 patients circulating anti-thyroglobulin antibody was also detected5. This evidence concerns the gene TG and hypothyroidism.