Additional major pigmentation-related genes identified in this study include TYR (tyrosinase; PWAS q-value = 6E−13 in non-melanoma skin cancer and q-value = 0.005 in melanoma) and SLC45A2 (solute carrier family 45 member 2; PWAS q-value = 1E−20 in non-melanoma skin cancer and q-value = 8E−5 in melanoma)50. The gene discussed is TYR; the disease is non-melanoma skin carcinoma.