In the case of MITF, we observe that among the 2,372 individuals with the lowest dominant effect scores (comprising 0.9% of the cohort), 61 (2.57% of that group) have had melanoma, compared to only 1.12% risk of melanoma in the rest of the cohort (leading to observed risk-ratio of 2.3). The gene discussed is MITF; the disease is melanoma.