HOXB13 and Familial prostate cancer: To illustrate the dominant and recessive genetic effects captured by PWAS, we selected three soliton associations with strong effects (see Table 1): MITF (melanocyte inducing transcription factor) associated with melanoma (q-value = 1E−08; both dominant and recessive effects are significant), HOXB13 (homeobox B13) associated with prostate cancer (q-value = 2E−31; only dominant effect is significant) and SLC45A2 (solute carrier family 45 member 2) associated with non-melanoma skin cancer (q-value = 1E−20; only recessive effect is significant).