The cytoplasmic tail of CD276 is short and has no known signaling motif, yet CD276 overexpression on tumor cells was reported to increase Jak2 and STAT3 phosphorylation16, therefore we speculated that any induction of downstream signaling might occur via a cis-partnership and one or more of the immunoreceptors expressed on macrophages are potential candidates. The gene discussed is JAK2; the disease is neoplasm.