BMI reductions may have stemmed from the nutritional interventions, increases in physical activity (mean (SD) steps taken per day increased from 4677.4 (2804.9) at baseline to 7004.1 (3999.0) at 90 days)26, the 63% reduction in fasting insulin level, and the reduction in average homeostatic model assessment of insulin resistance (HOMA-IR) from 7.4 (3.5) at baseline to 3.1 (2.5) at 30 days and 3.2 (2.8) at 90 days26. The gene discussed is INS; the disease is Insulin resistance.