In patients with mean duration of diabetes of 9.0 (6.0) years, Inzucchi et al. reported an increase in %CV from 21.0 to 25.7% and a decrease in HBGI from 15.4 to 5.3 in a 24-week study of type 2 diabetes patients who received an intensification of their insulin treatment35. Here, INS is linked to type 2 diabetes mellitus.