IL1B and systemic-onset juvenile idiopathic arthritis: However, dysregulated IL-1β production by the innate immune system may cause abberant local or systemic inflammation and lead to different types of autoinflammatory disorders, such as cryopyrin-associated periodic syndrome (CAPS)2, tumor necrosis factor receptor associated periodic syndrome (TRAPS)3, systemic juvenile idiopathic arthritis (SJIA)4 or chronic obstructive pulmonary disease (COPD)5.