The protein is shown in vitro to involved in cell survival and aggregation45, promoting metastasis of HCC46,47, protecting the HCC cells from endoplasmic reticulum stress induced apoptosis48, regulating the NF-κB pathway which controls the innate immune response of the cell, and affecting resistance to drugs (such as Sorafenib)49,50. This evidence concerns the gene NFKB1 and hepatocellular carcinoma.