CXCL2 and metastatic malignant neoplasm: Interestingly, several well-known oncogenes linked to aggressive and metastatic cancer phenotype, including CXCL1, CXCL2, MYC, and BMP4, were included in this gene get, suggesting that BRD4 and STAT3 can coordinately regulate the oncogenic enhancer activity to promote tumor progression.