The turnover of F4/80lowCD11c+ and F4/80lowCD11c− ATM subsets was of 100% in both control diet and HFD mice, and the turnover of F4/80highTim4− ATMs rose from 40% in control diet mice to 80% in HFD mice indicating that increased monocyte recruitment contributed to expansion of the ATM pool in obesity (Fig. 2h). Here, ATM is linked to obesity due to melanocortin 4 receptor deficiency.