Although the function of the exon inclusion or exclusion isoforms of CASP8 or PRMT1 was not investigated in the current work, the effects of PPM1G in alternative splicing and the clinical impact, functional importance of PPM1G in HCC highlighted the essential role of PPM1G-mediated alternative splicing during the progression of HCC. The gene discussed is PRMT1; the disease is hepatocellular carcinoma.