Owing to that the ROS metabolism in cancer is complicated and regulated by the interaction among multiple cellular signaling pathways, further experiments to intensely characterize the roles of GSTA2 in multiple ROS-mediated cellular signaling pathways such as NF-κB, MAPKs, Keapl-Nrf2-ARE, and PI3-AKT, are necessary to carry out in order to understand the molecular mechanisms of GSTA2 in regulating the ROS metabolism of HCC. The gene discussed is NFKB1; the disease is hepatocellular carcinoma.