Correlation analysis of the TCGA data showed that CARHSP1 mRNA level is positively correlated with TNF-α (P = 0.034) (Fig. 6A), which was proved in CARHSP1 knockdown and overexpression GBM cells by qPCR (P < 0.05) (Fig. 6B). This evidence concerns the gene CARHSP1 and glioblastoma.