Yet, it remains unclear if and to what extent the brain-age-protective mechanisms overlap with, for example, increased neural progenitor cells [44], brain derived neurotrophic factor (BDNF) [45], or other serotonergic neuroplasticity processes implicated in AD use [46], or, alternatively, whether neuropharmacology affects the MRI signal [47]. Here, BDNF is linked to Alzheimer disease.