A time-dependent rapid increase in the expression of BCL2, MMP9, E-CADHERIN, AKT, NF-kβ, and SNAIL and a moderate increase in VIMENTIN, C-MYC, CASP, CYCLIN1, SMAD, BAX, CDK4, LYNK1, and MMP2 similar to hallmark cell proliferation and metastasis regulator genes are observed in cancer cells over the coculture time due to platelets. This evidence concerns the gene CDK4 and cancer.