FUS and amyotrophic lateral sclerosis: Because both ALS-mutants cause a very aggressive disease in patients and NLS-lacking FUS mutants, such as FUS∆14, have a stronger mislocalization compared to NLS missense mutants, such as FUSP525L, this highlights how a combination of mislocalization and LLPS behavior can determine FUS cytoplasmic aberrant function and result in comparable cellular toxicity.