Since their discovery, Ca2+-permeable AMPARs (CPARs) have been implicated in the pathogenesis of various neurologic conditions, including epilepsy (Egbenya et al., 2018), amyotrophic lateral sclerosis, ischemic insult (Weiss, 2011), and AD (Gaisler-Salomon et al., 2014). The gene discussed is CA2; the disease is amyotrophic lateral sclerosis.