RFWD3 and hepatocellular carcinoma: We also identified unknown TSG implicated in HCC pathogenesis and negatively correlating with HBV-RNA, for example, RFWD3, encoding a E3 ubiquitin ligase stabilizing P53 expression (Fu et al, 2010), which has been already described as TSG in non-small cell lung cancer and hematological malignancies (Fig 4E).