In line with this, single-cell gene set enrichments revealed enrichment in HCC P1 for Boyault’s HCC subclass G5-G6, which is strongly related to beta-catenin mutations, higher tumor differentiation, and better patients’ survival, whereas Boyault’s subclass G1, representing less differentiated tumors with chromosome instability, is enriched in HCC P2 (Boyault et al, 2007) (Fig S3A and B). The gene discussed is CTNNB1; the disease is neoplasm.