HBV reads in single cells correlated negatively with RB1, encoding the tumor suppressor retinoblastoma 1, and TET1, encoding ten-eleven translocation methylcytosine dioxygenase 1, known for their role in HCC development (Tao et al, 2015; Kent et al, 2017) (Fig 4E). The gene discussed is RB1; the disease is hepatocellular carcinoma.