CD4 and cytomegalovirus infection: In the derived heatmap IFN-γ, CD10neg neutrophils, CD4+CD28null, EMRA, and EM CD4+ T-cells were grouped together showing similar patterns (Figure 8—figure supplement 1E), indicating that persistent CMV infection is associated with expansion of the effector memory CD4+ T-cell compartment and higher IFN-γ levels in patients with increased frequency of CD10neg neutrophils.