COL1A1 and Chagas disease: Three miRNAs are involved in biological mechanisms such as control of TRL- receptor (miR-146a), regulation of TGF- β (miR-21) and susceptibility to T. cruzi infection (miR-155) and their target genes are interleukin 1 receptor-associated kinase (Irak) 1, TNF receptor-associated factor (Traf) 6, Smad7 and collagen type I alpha 1 (Col1a1) [18–22] Currently, miRNAs have been suggested as therapeutic candidates and potential biomarkers for the diagnosis and early detection of cardiovascular diseases and various parasitic diseases, such as Chagas disease.