We found that among the 8 candidate CpGs (ITGB6:cg21105318, cg07896068, cg18437633; NCALD: cg27637873, cg26782361, cg16265707; LAMA3: cg20937934, cg13270625) in advanced high-grade serous ovarian cancer, the methylation level was highly positively correlated between any two CpGs, and the CpG correlation coefficient of the same gene was higher. Here, ITGB6 is linked to ovarian serous adenocarcinoma.