Severe MS-LCH has been associated with BRAF V600 mutation and has been treated with mercaptopurine, vinblastine, and systemic prednisone for 1 year, while mild SS-LCH has been treated with topical treatments such as nitrogen mustard or corticosteroids, or oral methotrexate. This evidence concerns the gene BRAF and Langerhans cell histiocytosis.