In this study, we aimed to advance upon previous work by investigating the association between semi-quantitative measures of four primary neurodegenerative pathologies (i.e. amyloid-β plaques, tau, α-synuclein and TDP-43) and the thickness of different MTL subregions measured on ultra high resolution postmortem MRI in a large dataset of brain donors with a broad range of neurodegenerative diagnoses but also some without any neurodegenerative disease. This evidence concerns the gene SNCA and neurodegenerative disease.