MAPT and Alzheimer disease: As an example, an immunotherapy that is developed to recognize specific sites of phosphorylation or conformation of aggregated tau may have variable translatability to symptomatic AD depending on whether a transgenic MAPT (e.g., P301L mutation resulting in an increased propensity for aggregation of 4-repeat (4R) tau or the R406W mutation which recapitulates AD tau pathology) mutation model is used or whether an injection model of tau aggregates isolated from AD brain homogenates is used.